Protein function prediction by collective classification with explicit and implicit edges in protein-protein interaction networks
نویسندگان
چکیده
منابع مشابه
Prediction of Protein Sub-Mitochondria Locations Using Protein Interaction Networks
Background: Prediction of the protein localization is among the most important issues in the bioinformatics that is used for the prediction of the proteins in the cells and organelles such as mitochondria. In this study, several machine learning algorithms are applied for the prediction of the intracellular protein locations. These algorithms use the features extracted from pro...
متن کاملProtein Interaction Networks: Protein Domain Interaction and Protein Function Prediction
Most of a cell’s functional processes involve interactions among proteins, and a key challenge in proteomics is to better understand these complex interaction graphs at a systems level. Because of their importance in development and disease, protein-protein interactions (PPIs) have been the subject of intense research in recent years. In addition, a greater understanding of PPIs can be achieved...
متن کاملGlobal protein function prediction in protein-protein interaction networks
A. Vazquez, A. Flammini, A. Maritan and A. Vespignani 1 Department of Physics, University of Notre Dame, Notre Dame, IN 46556, USA 2 International School for Advanced Studies (SISSA) and INFM, V. Beirut 2-4, 34014 Trieste, Italy 3 The Abdus Salam International Centre for Theoretical Physics, P.O. Box 586, 34100 Trieste, Italy and 4 Laboratoire de Physique Theorique (UMR du CNRS 8627), atiment 2...
متن کاملConstruction and Analysis of Tissue-Specific Protein-Protein Interaction Networks in Humans
We have studied the changes in protein-protein interaction network of 38 different tissues of the human body. 123 gene expression samples from these tissues were used to construct human protein-protein interaction network. This network is then pruned using the gene expression samples of each tissue to construct different protein-protein interaction networks corresponding to different studied ti...
متن کاملProtein Function Prediction Using Protein–Protein Interaction Networks
Proteins perform biological functions by participating in a large number of interactions, ranging from transient interactions in signaling pathways to permanent interactions within stable complexes. Studies have shown that the immediate interaction neighborhood of a protein can be used to infer its functions. While using only such direct interactions limits prediction coverage, extending the in...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMC Bioinformatics
سال: 2013
ISSN: 1471-2105
DOI: 10.1186/1471-2105-14-s12-s4